ERC Consolidator Grant 2020, ERC-CoG-2020-101001916. “HumAN: Interrogating human adult hippocampal neurogenesis”.
Understanding the functional integration of new neurons to promote human brain plasticity.
The addition of new neurons to the hippocampus is a unique mechanism of plasticity that occurs in the adult mammalian brain. Our group has pioneered state-of-the-art tissue preservation and processing methodologies, thereby demonstrating the persistence of adult neurogenesis up to, at least, the tenth decade of human life. We aim at gaining mechanistic insight into the regulation of human adult hippocampal neurogenesis during physiological and pathological aging. For that purpose, we will precisely reconstruct the entire life of new neurons generated in the adult human hippocampus and dissect, at the single-cell level, the pathological mechanisms that converge into the functional failure of adult hippocampal neurogenesis in neurodegenerative and psychiatric diseases.